F594-1001 [1215326-44-5]

TargetMol Chemicals

F594-1001 [1215326-44-5]

9

Research Use Only

C23H28ClN3O4

445.94

F594-1001 (compound 6) serves as a potent, highly selective inhibitor of SARS-CoV-2 Mac1-ADP-ribose, displaying IC 50 values of 8.5 microM, 68 microM, and 45 microM in AS, FP, and FRET assays, respectively. It binds directly to SARS-CoV-2 Mac1 and demonstrates dose-dependent inhibition of Mac1 ADP-ribosylhydrolase activity.

O=C(C=1C=C(OC)C=C(OC)C1)N(CC=2C=CC=C(Cl)C2)CCC(=O)N3CCNCC3

-20°C

12352200