![Fas (TNFRSF6) associated factor 1(CPTC-FAF1-2), CF405S conjugate, 0.1mg/mL [26628-22-8] Fas (TNFRSF6) associated factor 1(CPTC-FAF1-2), CF405S conjugate, 0.1mg/mL [26628-22-8]](https://biotium.com/wp-content/uploads/2021/02/view_image-56.jpeg)
Fas (TNFRSF6) associated factor 1(CPTC-FAF1-2), CF405S conjugate, 0.1mg/mL [26628-22-8]
BNC042268
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityBovine, Human, Mouse
TargetFAF1
Overview
- SupplierBiotium
- Product NameFas (TNFRSF6) associated factor 1(CPTC-FAF1-2), CF405S conjugate, 0.1mg/mL
- Delivery Days Customer9
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDCPTC-FAF1-2
- Concentration0.1 mg/ml
- ConjugateOther Conjugate
- Gene ID11124
- Target nameFAF1
- Target descriptionFas associated factor 1
- Target synonymsCGI-03; Fas (TNFRSF6) associated factor 1; FAS-associated factor 1; hFAF1; HFAF1s; TNFRSF6-associated factor 1; UBX domain protein 3A; UBX domain-containing protein 12; UBX domain-containing protein 3A; UBXD12; UBXN3A
- HostMouse
- IsotypeIgG2b
- Protein IDQ9UNN5
- Protein NameFAS-associated factor 1
- Scientific DescriptionIn contrast to growth factors which promote cell proliferation, FAS ligand (FAS-L) and the tumor necrosis factors (TNFs) rapidly induce apoptosis. Cellular response to FAS-L and TNF is mediated by structurally related receptors containing a conserved death domain and belonging to the TNF receptor superfamily. TRADD, FADD and RIP are FAS/TNF-RI interacting proteins that contain a death domain homologous region (DDH). TRADD (TNF-RI-associated death domain) and FADD (FAS-associated death domain) associate with the death domains of both FAS and TNF-RI via their DDH regions, while RIP associates exclusively with FAS. An additional FAS interacting protein designated FAF1, for FAS-associated protein factor-1, binds with the cytoplasmic tail of wildtype but not LPR mutant FAS. When overexpressed in cells, FAF1 enhances the efficiency of FAS-mediated apoptosis. In contrast to TRADD, FADD and RIP, FAF1 lacks a DDH and cannot induce apoptosis independently of FAS activation. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- SourceAnimal
- ReactivityBovine, Human, Mouse
- Storage Instruction2°C to 8°C
- UNSPSC12352203