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Fas (TNFRSF6) associated factor 1(CPTC-FAF1-2), CF405S conjugate, 0.1mg/mL [26628-22-8]

Fas (TNFRSF6) associated factor 1(CPTC-FAF1-2), CF405S conjugate, 0.1mg/mL [26628-22-8]

BNC042268
Biotium
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityBovine, Human, Mouse
TargetFAF1
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Overview

  • Supplier
    Biotium
  • Product Name
    Fas (TNFRSF6) associated factor 1(CPTC-FAF1-2), CF405S conjugate, 0.1mg/mL
  • Delivery Days Customer
    9
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    CPTC-FAF1-2
  • Concentration
    0.1 mg/ml
  • Conjugate
    Other Conjugate
  • Gene ID11124
  • Target name
    FAF1
  • Target description
    Fas associated factor 1
  • Target synonyms
    CGI-03; Fas (TNFRSF6) associated factor 1; FAS-associated factor 1; hFAF1; HFAF1s; TNFRSF6-associated factor 1; UBX domain protein 3A; UBX domain-containing protein 12; UBX domain-containing protein 3A; UBXD12; UBXN3A
  • Host
    Mouse
  • Isotype
    IgG2b
  • Protein IDQ9UNN5
  • Protein Name
    FAS-associated factor 1
  • Scientific Description
    In contrast to growth factors which promote cell proliferation, FAS ligand (FAS-L) and the tumor necrosis factors (TNFs) rapidly induce apoptosis. Cellular response to FAS-L and TNF is mediated by structurally related receptors containing a conserved death domain and belonging to the TNF receptor superfamily. TRADD, FADD and RIP are FAS/TNF-RI interacting proteins that contain a death domain homologous region (DDH). TRADD (TNF-RI-associated death domain) and FADD (FAS-associated death domain) associate with the death domains of both FAS and TNF-RI via their DDH regions, while RIP associates exclusively with FAS. An additional FAS interacting protein designated FAF1, for FAS-associated protein factor-1, binds with the cytoplasmic tail of wildtype but not LPR mutant FAS. When overexpressed in cells, FAF1 enhances the efficiency of FAS-mediated apoptosis. In contrast to TRADD, FADD and RIP, FAF1 lacks a DDH and cannot induce apoptosis independently of FAS activation. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
  • Source
    Animal
  • Reactivity
    Bovine, Human, Mouse
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203