Fasudil (mesylate)

MedChem Express

Fasudil (mesylate)

14

Research Use Only

C15H21N3O5S2

387.47

Fasudil (HA-1077; AT877) mesylate is a nonspecific and orally active RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an K i of 0.33 microM for ROCK1 , IC 50 s of 0.158 microM and 4.58 microM, 12.30 microM, 1.650 microM for ROCK2 and PKA , PKC , PKG , respectively. Fasudil mesylate is also a potent Ca 2+ channel antagonist and vasodilator [1] [2] [3] [4] [5] [6] .

CS(O)(=O)=O.O=S(C1=CC=CC2=C1C=CN=C2)(N3CCNCCC3)=O

12352200