Oligomerisation of FasL (h) efficiently triggers Jurkat cell death.Method: Jurkat cells were treated O/N with the indicated concentrations of MegaFasL, Soluble (human) (rec.) (Prod. No. AG-40B-0130), Fc:FasL, Soluble (human) (rec.) (Pr
Oligomerisation of FasL (h) efficiently triggers Jurkat cell death.Method: Jurkat cells were treated O/N with the indicated concentrations of MegaFasL, Soluble (human) (rec.) (Prod. No. AG-40B-0130), Fc:FasL, Soluble (human) (rec.) (Pr
Fc (human):FasL, Soluble (human) (rec.)
AG-40B-0132
Overview
- SupplierAdipoGen Life Sciences
- Product NameFc (human):FasL, Soluble (human) (rec.)
- Delivery Days Customer10
- CertificationResearch Use Only
- Concentration0.1 mg/ml
- Estimated Purity>95%
- Protein IDP48023
- Protein NameTumor necrosis factor ligand superfamily member 6
- Scientific DescriptionFc (human):FasL, Soluble (human) is a high activity construct in which two trimeric FasL are artificially linked via the Fc binding domain of human IgG1. This construct very effectively simulates the natural membrane-assisted aggregation of FasL in vivo. FasL is a cytokine that binds to TNFRSF6/Fas, a receptor that transduces the apoptotic signal into cells. It is involved in cytotoxic T cell mediated apoptosis and in T cell development. - Protein. Human FasL (aa 139-281) is fused at the N-terminus to the Fc portion of human IgG1. Source: HEK 293 cells. Endotoxin content: <0.01EU/microg purified protein (LAL test; Lonza). Lyophilized. Contains PBS. Binds to human and mouse Fas. Purity: >95% (SDS-PAGE). Fc (human):FasL, Soluble (human) is a high activity construct in which two trimeric FasL are artificially linked via the Fc binding domain of human IgG1. This construct very effectively simulates the natural membrane-assisted aggregation of FasL in vivo. FasL is a cytokine that binds to TNFRSF6/Fas, a receptor that transduces the apoptotic signal into cells. It is involved in cytotoxic T cell mediated apoptosis and in T cell development.
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352202