FE65 antibody

GeneTex

FE65 antibody - KO/KD Validated

9

This antibody does not detect endogenous levels of Fe65.

WB: 1-2 microg/ml. ICC/IF: 2 microg/ml. FACS: 3-5 microg/106 cells. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

Apbb1

amyloid beta (A4) precursor protein-binding, family B, member 1

amyloid-beta A4 precursor protein-binding family B member 1; Fe65; Rir

Rabbit

IgG

Amyloid-beta A4 precursor protein-binding family B member 1

The major transcript of the Fe65 gene is a neuron-specific mRNA that encodes a nuclear protein whose amino-terminal domain strongly activates the transcription of reporter genes. Fe65 has been implicated in a regulatory and cell signaling mechanism because it contains two different motifs involved in protein binding; a WW domain (a variant of Src homology 3 domains) and a phosphotyrosine interaction domain (PID). Interestingly, the PID domain binds to the same motif present in the conserved cytoplasmic domains of the beta PP and beta PP-like proteins. RNA analyses revealed that Fe65 is predominantly expressed in the brain and in the regions most affected by Alzheimers disease-associated neuropathology.

Human, Mouse, Rat

-20°C or -80°C,2°C to 8°C

12352203