FEN1 Antibody

Cusabio

FEN1 Antibody

20

ImmunoFluorescence, Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

FEN1

flap structure-specific endonuclease 1

DNase IV; FEN-1; flap endonuclease 1; maturation factor-1; MF1; RAD2

Rabbit

IgG

Flap endonuclease 1

Structure-specific nuclease with 5-flap endonuclease and 5-3 exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5-end of a downstream Okazaki fragment. It enters the flap from the 5-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5-3 exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. Murray J.M., Mol. Cell. Biol. 14:4878-4888(1994). Hiraoka L.R., Genomics 25:220-225(1995). Taylor T.D., Nature 440:497-500(2006).

Human

-20°C or -80°C

12352203