FEN1 Antibody, FITC conjugated

Cusabio

FEN1 Antibody, FITC conjugated

20

Research Use Only

Polyclonal

FITC

Rabbit

IgG

Structure-specific nuclease with 5\-flap endonuclease and 5\-3\ exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5\-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5\-end of a downstream Okazaki fragment. It enters the flap from the 5\-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinicapyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5\-3\ exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.

Plant

-20°C or -80°C

12352203