FEN1-IN-7

MedChem Express

FEN1-IN-7

14

Research Use Only

99.92

C16H14N2O6S

362.36

FEN1-IN-7 (compound 16) is a selective inhibitor of Flap endonuclease-1 (FEN1, IC50=18 nM), involving in mammalian cells to repair DNA damage. FEN1-IN-7 also targets to related endonuclease, xeroderma pigmentosum G (XPG) with an IC50 value of 3.04 microM. FEN1-IN-7 increases the cellular sensitivity of cancer cells to potent DNA alkylating agents or methylating agents[1].

O=C1C2=C(N(CC3=CC(OC)=C4OCOC4=C3)C(N1O)=O)SC=C2C

2°C to 8°C

12352200