Feralolide, a dihydroisocoumarin from the methanolic extract of aloe vera resin, functions as a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), with IC50 values of 55 microg/mL and 52 microg/mL, respectively. It exhibits antioxidant properties, effectively inhibiting 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS). Research suggests feralolides potential in studying cognitive disorders, including Alzheimers disease, for its memory restoration and enhancement capabilities [1].
