FG 7142

MedChem Express

FG 7142 [78538-74-6]

10

78538-74-6

Research Use Only

98.16

C13H11N3O

225.25

FG 7142 (ZK 39106; LSU-65), a non-selectively benzodiazepine inverse agonist, has high affinity for the alpha1 subunit-containing GABAA receptor ( K i =91 nM). FG 7142 (ZK 39106; LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the alpha1 subunit ( EC 50 = 137 nM). FG 7142 (ZK 39106; LSU-65) can increase tyrosine hydroxylation and cause upregulation of?beta-adrenoceptors in mouse cerebral cortex [1] .

O=C(C1=CC2=C(C=N1)NC3=C2C=CC=C3)NC

-20°C,2°C to 8°C

12352200