Fibulin 5 Polyclonal Antibody
RD76260A
ApplicationsELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetFBLN5
Overview
- SupplierReddot Biotech
- Product NameFibulin 5 Polyclonal Antibody
- Delivery Days Customer5
- ApplicationsELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1.2 mg/ml
- ConjugateUnconjugated
- Gene ID10516
- Target nameFBLN5
- Target descriptionfibulin 5
- Target synonymsADCL2; ARCL1A; ARMD3; DANCE; developmental arteries and neural crest EGF-like protein; embryonic vascular EGF-like repeat-containing protein; EVEC; FIBL-5; fibulin-5; HNARMD; testis tissue sperm-binding protein Li 75n; UP50; urine p50 protein
- HostRabbit
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3).
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C
- UNSPSC12352203