Filibuvir
HY-10118
Overview
- SupplierMedChem Express
- Product NameFilibuvir [877130-28-4]
- Delivery Days Customer10
- CAS Number877130-28-4
- Estimated Purity99.0
- Molecular FormulaC29H37N5O3
- Molecular Weight503.64
- Scientific DescriptionFilibuvir is an orally active, selective non-nucleoside inhibitor of the HCV nonstructural 5B protein (NS5B) RNA-dependent RNA polymerase (RdRp) . Filibuvir binds noncovalently in the thumb II allosteric pocket of NS5B. Filibuvir inhibits genotype 1a and 1b replicons with EC 50 s of 59 nM for both isoforms, respectively [1] . Filibuvir preferentially inhibits elongative RNA synthesis and potently decreases viral RNA accumulation [2] .
- SMILESO=C(O1)C(CC2=NN(C(C)=C3)C(N=C3C)=N2)=C(O)C[C@@]1(C4CCCC4)CCC5=CC(CC)=NC(CC)=C5
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200