Bio-Connect

Filibuvir

HY-10118
MedChem Express
CAS Number877130-28-4
Product group Chemicals
Estimated Purity99.0
Molecular Weight503.64
Sign in to order and to see your custom pricing.
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    MedChem Express
  • Product Name
    Filibuvir [877130-28-4]
  • Delivery Days Customer
    10
  • CAS Number
    877130-28-4
  • Estimated Purity
    99.0
  • Molecular Formula
    C29H37N5O3
  • Molecular Weight
    503.64
  • Scientific Description
    Filibuvir is an orally active, selective non-nucleoside inhibitor of the HCV nonstructural 5B protein (NS5B) RNA-dependent RNA polymerase (RdRp) . Filibuvir binds noncovalently in the thumb II allosteric pocket of NS5B. Filibuvir inhibits genotype 1a and 1b replicons with EC 50 s of 59 nM for both isoforms, respectively [1] . Filibuvir preferentially inhibits elongative RNA synthesis and potently decreases viral RNA accumulation [2] .
  • SMILES
    O=C(O1)C(CC2=NN(C(C)=C3)C(N=C3C)=N2)=C(O)C[C@@]1(C4CCCC4)CCC5=CC(CC)=NC(CC)=C5
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200