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ProductsBack/Fipronil [120068-37-3]
Chemical Structure
Chemical Structure
Chemical Structure

Fipronil [120068-37-3]

Research Use Only
AG-CR1-3648
AdipoGen Life Sciences
CAS Number120068-37-3
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight437.2
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Fipronil [120068-37-3]
  • Delivery Days Customer
    10
  • ADR Class
    6.1
  • CAS Number
    120068-37-3
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Danger,Excepted quantity
  • Molecular Formula
    C12H4Cl2F6N4OS
  • Molecular Weight
    437.2
  • Scientific Description
    Alzheimer inducing agent (Alzheimerogen). Potent GABA receptor alpha-4 subunit and beta-3 subunit inhibitor. Broad-range insecticide. Blocks GABA A-gated chloride channels and glutamate-activated chloride channels (GluCls) in the central nervous system, resulting in overexcitation of the insects nervous system and muscles. Induces oxidative stress in mouse kidney and brain. Increases CYP1A1, CYP2B6, CYP3A4 and CYP3A5 transcript, protein and enzyme activity levels. - Chemical. CAS: 120068-37-3. Formula: C12H4Cl2F6N4OS. MW: 437.2. Alzheimer inducing agent (Alzheimerogen). Potent GABA receptor alpha-4 subunit and beta-3 subunit inhibitor. Broad-range insecticide. Blocks GABA A-gated chloride channels and glutamate-activated chloride channels (GluCls) in the central nervous system, resulting in overexcitation of the insects nervous system and muscles. Induces oxidative stress in mouse kidney and brain. Increases CYP1A1, CYP2B6, CYP3A4 and CYP3A5 transcript, protein and enzyme activity levels.
  • SMILES
    ClC1=C(N2N=C(C#N)C(S(C(F)(F)F)=O)=C2N)C(Cl)=CC(C(F)(F)F)=C1
  • Storage Instruction
    2°C to 8°C,RT
  • UN Number
    UN 2811
  • UNSPSC
    12352200

References

  • Action of Phenylpyrazole Insecticides at the GABA-Gated Chloride Channel: L.M. Cole, et al.; Pestic. Biochem. Physiol. 46, 47 (1993)
  • Actions of the insecticide fipronil, on dieldrin-sensitive and -resistant GABA receptors of Drosophila melanogaster: A.M. Hosie, et al.; Br. J. Pharmacol. 115, 909 (1995)
  • Ion channels: molecular targets of neuroactive insecticides: V. Raymond-Delpech, et al.; Invert. Neurosci. 5, 119 (2005)
  • Glutamate-activated chloride channels: Unique fipronil targets present in insects but not in mammals: T. Narahashi, et al.: Pestic. Biochem. Physiol. 97, 149 (2010)
  • Fipronil induced oxidative stress in kidney and brain of mice: protective effect of vitamin E and vitamin C: P.C. Badgujar, et al.; Pestic. Biochem. Physiol. 118, 10 (2015)
  • Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration: B.L. Pearson, et al.; Nat. Commun. (2015)
  • Specific triazine herbicides induce amyloid-beta42 production: E. Portelius, et al.; J. Alzheimers Dis. 54, 1593 (2016)
  • Impact of environmental chemicals on the transcriptome of primary human hepatocytes: Potential for health effects: R.D. Mitchell, et al.; J. Biochem. Mol. Toxicol. 30, 375 (2016)