FK-866 [658084-64-1]

Name: FK-866 [658084-64-1]
SKU: AG-CR1-0011_A27
Price: 42 EUR
Availability: BackOrder

AG-CR1-0011

CAS Number658084-64-1

Product group Chemicals

Estimated Purity>98%

Molecular Weight391.5

Overview

Supplier
AdipoGen Life Sciences
Product Name
FK-866 [658084-64-1]
Delivery Days Customer
10
CAS Number
658084-64-1
Certification
Research Use Only
Estimated Purity
>98%
Hazard Information
Warning
Molecular Formula
C24H29N3O2
Molecular Weight
391.5
Scientific Description
Chemical. CAS: 658084-64-1. Formula: C24H29N3O2. MW: 391.5. Nampt/visfatin inhibitor. Inhibitor of NAD+ biosynthesis. Inhibits the enzyme/substrate complex and the free enzyme (Ki = 0.4 nM and Ki = 0.3 nM, respectively). Apoptosis inducer. Autophagy inducer. Causes premature senescence. Angiogenesis inhibitor. - Nampt/visfatin inhibitor [1]. Inhibitor of NAD+ biosynthesis [1]. Inhibits the enzyme/substrate complex and the free enzyme (Ki = 0.4 nM and Ki = 0.3 nM, respectively) [1]. Apoptosis inducer [1]. Autophagy inducer [2]. Causes premature senescence [3]. Angiogenesis inhibitor [4].
SMILES
O=C(NCCCCC1CCN(CC1)C(=O)C1=CC=CC=C1)\C=C\C1=CC=CN=C1
Storage Instruction
-20°C,2°C to 8°C
UNSPSC
12352200

FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis: M. Hasmann & I. Schemainda; Cancer Res. 63, 7436 (2003)
NAD depletion by FK866 induces autophagy: R.A. Billington, et al.; Autophagy 4, 385 (2008)
Extension of human cell lifespan by nicotinamide phosphoribosyltransferase: E. van der Veer, et al.; J. Biol. Chem. 282, 10841 (2007)
Antiangiogenic potency of FK866/K22.175, a new inhibitor of intracellular NAD biosynthesis, in murine renal cell carcinoma: J. Drevs, et al.; Anticancer Res. 23, 4853 (2003)