FLI1 (Ewing s Sarcoma & Endothelial Marker) (FLI1/1312), CF568 conjugate, 0.1mg/mL [26628-22-8]

Biotium

FLI1 (Ewing s Sarcoma & Endothelial Marker) (FLI1/1312), CF568 conjugate, 0.1mg/mL

9

Western Blot

Research Use Only

Monoclonal

FLI1/1312

0.1 mg/ml

Other Conjugate

FLI1

Fli-1 proto-oncogene, ETS transcription factor

BDPLT21; Ewing sarcoma breakpoint region 2; EWSR2; Friend leukemia integration 1 transcription factor; Friend leukemia virus integration 1; SIC-1; transcription factor ERGB

Mouse

IgG

Friend leukemia integration 1 transcription factor

This antibody recognizes a protein of 51 kDa, which is identified as FLI1. This protein, a member of the ETS family of DNA binding transcription factors, is involved in cellular proliferation and tumorigenesis. Ets-1 is the prototype member of a family of genes identified on the basis of homology to the v-Ets oncogene isolated from the E26 erythroblastosis virus.Members of the Ets gene family share a highly conserved carboxy-terminal domain containing a sequence related to the SV40 large T antigen nuclear localization signal sequence. Approximately 90% of Ewing s Sarcoma (EWS)/Primitive Neuroectodermal Tumors (PNET) have a specific translocation, t(11;22)(q24;q12), which results in fusion of EWS to Fli-1, and production of an EWS-Fli-1 fusion protein. Among normal tissues only endothelial cells and small lymphocytes express Fli-1. This protein is expressed in majority of vascular tumors including angiosarcomas, hemangioendotheliomas, hemangiomas, and Kaposis Sarcomas. High sensitivity and specificity of Fli-1 equals to or exceeds that of the established vascular markers like CD31, CD34, and Factor VIII.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

Bovine, Human, Mouse

2°C to 8°C

12352203