FLT3 Antibody, Biotin conjugated

Cusabio

FLT3 Antibody, Biotin conjugated

20

ELISA

Research Use Only

Polyclonal

Biotin

FLT3

fms related receptor tyrosine kinase 3

CD135; CD135 antigen; fetal liver kinase 2; FL cytokine receptor; FLK2; FLK-2; fms related tyrosine kinase 3; fms-like tyrosine kinase 3; growth factor receptor tyrosine kinase type III; receptor-type tyrosine-protein kinase FLT3; stem cell tyrosine kinase 1; STK1

Rabbit

IgG

Receptor-type tyrosine-protein kinase FLT3

Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

Human

-20°C or -80°C

12352203