FNDR-20123
HY-131708A
Overview
- SupplierMedChem Express
- Product NameFNDR-20123
- Delivery Days Customer10
- CertificationResearch Use Only
- Estimated Purity98.08
- Molecular FormulaC21H24ClN5O2
- Molecular Weight413.90
- Scientific DescriptionFNDR-20123 is a safe, first-in-class, and orally active anti-malarial HDAC inhibitor with IC 50 s of 31 nM and 3 nM for Plasmodium and human HDAC, respectively. FNDR-20123 exerts anti-malarial activity against Plasmodium falciparum asexual stage (IC 50 =41 nM) and sexual blood stage (IC 50 =190 nM for male gametocytes). FNDR-20123 inhibits HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 (IC 50 =25/29/2/11/282 nM, respectively.) and inhibits Class III HDAC isoforms at nanomolar concentrations [1] .
- SMILESO=C(NO)C1=CC=C(CN2N=NC(C3=CC=C(CN4CCCC4)C=C3)=C2)C=C1.[H]Cl
- Storage Instruction2°C to 8°C
- UNSPSC12352200