FNIP2 antibody

GeneTex

FNIP2 antibody

9

Multiple isoforms of FNIP2 are known to exist. This antibody is predicted to not cross-react with FNIP1.

WB: 1 - 2 microg/mL. IHC-P: 5 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

FNIP2

folliculin interacting protein 2

FNIP1-like protein; FNIPL; folliculin-interacting protein 2; MAPO1; O6-methylguanine-induced apoptosis 1 protein

Rabbit

IgG

Folliculin-interacting protein 2

FNIP2 is the second protein found to interact with folliculin, the product of the Birt-Hogg-Dube (BHD) gene. Folliculin is thought to act as a tumor suppressor as mutations or loss of heterozygosity in this gene are associated with BHD syndrome-related renal tumors. Folliculin and FNIP1, a protein that shares 49% identity to FNIP2, bind to AMPK, an important energy sensor in cells that negatively regulates the mammalian target of rapamycin (mTOR), a protein that is thought to be the master switch for cell growth and proliferation. FNIP1 and FNIP2 are able to form homo- and heteromeric multimers, suggesting these proteins may have a functional relationship. Multiple isoforms of FNIP2 are known to exist. This antibody is predicted to not cross-react with FNIP1.

Human, Mouse, Rat

-20°C or -80°C,2°C to 8°C

12352203