Formoterol (fumarate)

MedChem Express

Formoterol (fumarate)

9

43229-80-7

Research Use Only

99.95

C19H24N2O4.1/2C4H4O4

402.44

Formoterol fumarate (Formoterol) is a potent, selective and long-acting beta2-adrenoceptor agonist. IC50 Value: 2.1 nM in pregnant C3H/HeN strain mice[5] Target: beta2 receptor Budesonide/formoterol in a single inhaler for both maintenance and reliever therapy is now an established therapeutic option for management of inadequately controlled asthma[4]. in vitro:. The long-acting beta(2)-agonist formoterol and the glucocorticoid dexamethasone significantly reduced HRV-induced ERK phosphorylation, Fra-1, and MMP-9 expression in BEAS-2B cells[3]. in vivo: compared the bronchodilatory effects of inhaled budesonide/formoterol (dose: 200 microg and 12 microg respectively) combination with budesonide (200 microg)/salbutamol (200 microg) administered by metered dose inhaler and spacer in children of 5-15 years with mild acute exacerbation of asthma [Modified Pulmonary Index Score (MPIS) between 6-8] in this double-blind, randomized controlled trial. The primary outcome was FEV1 (% predicted) in the two groups at 1, 5, 15, 30, 60 min after administration of the study drug[1]. Fifteen randomized, placebo-controlled clinical trials including COPD patients were evaluated: indacaterol 75 microg once daily (n = 2 studies), indacaterol 150 microg once daily (n = 5), indacaterol 300 microg once daily (n = 4), FOR/BUD 9/160 microg twice daily (n = 2), FOR/BUD 9/320 microg twice daily (n = 2), SAL/FP 50/500 microg twice daily (n = 4), and SAL/FP 50/250 microg twice daily (n = 1)[2]. Clinical trial: Effects of Mometasone Furoate/Formoterol Combination Versus Mometasone Furoate Alone in Persistent Asthmatics (Study P04073) . Phage3

O=CNC1=CC([C@@H](O)CN[C@H](C)CC2=CC=C(OC)C=C2)=CC=C1O.O=C(O)/C=C/C(O)=O.[1/2]

2°C to 8°C

12352200