Fosaprepitant-d4 Dimeglumine

TargetMol Chemicals

Fosaprepitant-d4 Dimeglumine

16

Research Use Only

C37H52D4F7N6O16P

1008.86

Fosaprepitant-d4 Dimeglumine is a deuterated compound of Fosaprepitant Dimeglumine. Fosaprepitant Dimeglumine has a CAS number of 265121-04-8. Fosaprepitant Dimeglumine is the dimeglumine salt form of fosaprepitant, the water-soluble, N-phosphorylated prodrug of aprepitant, with antiemetic activity. Upon intravenous administration and rapid conversion to aprepitant, this agent binds selectively to the human substance P/neurokinin 1 (NK1) receptors in the central nervous system (CNS). This inhibits receptor binding of the endogenous substance P and prevents substance P-induced emesis.

C[C@@H](O[C@H]1OC([2H])([2H])C([2H])([2H])N(CC2NC(=O)N(P(O)(O)=O)N=2)[C@H]1C1C=CC(F)=CC=1)C1C=C(C(F)(F)F)C=C(C(F)(F)F)C=1.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

-20°C

12352200