FOXA2 antibody [3C10]

GeneTex

FOXA2 antibody [3C10] - Overexpression Validated

9

WB: 1:1000. ICC/IF: 1:50-1:100. IHC-P: 1:50. FACS: 1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

3C10

1 mg/ml

Liquid

FOXA2

forkhead box A2

forkhead box protein A2; hepatic nuclear factor-3-beta; hepatocyte nuclear factor 3-beta; HNF3B; HNF-3-beta; TCF3B; transcription factor 3B

Hepatocyte nuclear factor 3-beta

Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a pioneer factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3 (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs - FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally discribed as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis - regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.

-20°C or -80°C,2°C to 8°C

12352203