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ProductsBack/FR-167356 [174185-16-1]
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FR-167356 [174185-16-1]

Research Use Only
T27371
TargetMol Chemicals
Molecular Weight378.25
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Product group Chemicals
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    FR-167356 [174185-16-1]
  • Delivery Days Customer
    4
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    FR-167356
  • Molecular Formula
    C19H17Cl2NO3
  • Molecular Weight
    378.25
  • Scientific Description
    FR-167356 is a specific inhibitor of a3 isoform vacuolar type H+-ATPase with IC50s of 170 nM, 370 nM and 220 nM for osteoclast plasma membranes, renal brush border membranes and macrophage microsomes. FR-167356 reduces bone metastasis of B16-F10 cells.
  • Shelf life instruction
    3 years
  • SMILES
    C(C)(C)(O)C=1C=2C(=C(NC(=O)C3=C(Cl)C=CC=C3Cl)C=CC2)OC1C
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Nishisho T, et al. The a3 isoform vacuolar type H⁺-ATPase promotes distant metastasis in the mouse B16 melanoma cells. Mol Cancer Res. 2011 Jul;9(7):845-55.
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