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Furamidine

T11338
TargetMol Chemicals
CAS Number73819-26-8
Product group Chemicals
Molecular Weight304.35
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    Furamidine
  • Delivery Days Customer
    72
  • CAS Number
    73819-26-8
  • Category Supplier
    Chemical
  • Chemical Name
    Furamidine
  • Molecular Formula
    C18H16N4O
  • Molecular Weight
    304.35
  • Scientific Description
    Furamidine is also a selective and cell-permeable protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 uM. Furamidine is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 uM, 283 uM, and >400 uM, respectively). Furamidine (DB75) is abisbenzamidine derivative and an antiparasite agent. Furamidine is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA.
  • Shelf life instruction
    3 years
  • SMILES
    C(=N)(N)C1=CC=C(C=2OC(=CC2)C3=CC=C(C(=N)N)C=C3)C=C1
  • Storage Instruction
    -20°
  • UNSPSC
    12352200

References

  • Antony S, et al. Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1. Nucleic Acids Res. 2007;35(13):4474-84.
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