FXR agonist 3

TargetMol Chemicals

FXR agonist 3

16

Chemical

Research Use Only

FXR agonist 3

0.9504

C28H28BrNO4

521.12

FXR agonist 3 is an anti-NASH compound with antifibrotic and anti-fibrotic activity, inhibiting the expression of COL1A1, TGF-beta1, alpha-SMA, and TIMP1, with an IC50 value of 8.19 micromol/L for COL1A1. FXR agonist 3 ameliorates CDAHFD and BDL-induced liver injury in vivo by activating FXR.

3 years

COC1=CC2=C(C=C1OC)CC[N+]3=C2C=C4C(C(OCC5=CC=CC(C)=C5)=C(OC)C=C4)=C3.[Br-]

-20°C

12352200