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ProductsBack/G418 . sulfate [108321-42-2]
Chemical Structure
Chemical Structure
Chemical Structure

G418 . sulfate [108321-42-2]

Research Use Only
AG-CN2-0030
AdipoGen Life Sciences
CAS Number108321-42-2
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight496.6 . 196.1
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    G418 . sulfate [108321-42-2]
  • Delivery Days Customer
    10
  • CAS Number
    108321-42-2
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Warning
  • Molecular Formula
    C20H40N4O10 . 2H2SO4
  • Molecular Weight
    496.6 . 196.1
  • Scientific Description
    Antibiotic [1]. Cytotoxic to prokaryotic and eukaryotic cells by inhibiting the protein synthesis [1, 3, 4, 6]. Apoptosis inducer [5]. Widely employed in the selection of eukaryotic expression vectors, in combination with either aminoglycoside phosphotransferase 3 or APH II [2]. Antiviral [7, 8]. - Chemical. CAS: 108321-42-2. Formula: C20H40N4O10 . 2H2SO4. MW: 496.6 . 196.1. Isolated from Micromonospora rhodorangea. Antibiotic. Cytotoxic to prokaryotic and eukaryotic cells by inhibiting the protein synthesis. Apoptosis inducer. Widely employed in the selection of eukaryotic expression vectors, in combination with either aminoglycoside phosphotransferase 3 or APH II. Antiviral.
  • SMILES
    [H]N(C)C1C(O)C(OC2C(N)CC(N)C(OC3OC(C(C)O)C(O)C(O)C3N)C2O)OCC1(C)O
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Antibiotic G-418, a new Micromonospora-produced aminoglycoside with activity against protozoa and helminths: fermentation, isolation, and preliminary characterization: G.H. Wagman, et al.; Antimicrob. Agents Chemother. 6, 144 (1974)
  • Phosphatidylinositol phospholipase C is activated allosterically by the aminoglycoside G418. 2-deoxy-2-fluoro-scyllo-inositol-1-O-dodecylphosphonate and its analogs inhibit glycosylphosphatidylinositol phospholipase C: J.C. Morris, et al.; J. Biol. Chem. 271, 15468 (1996)
  • Addition of G418 and other aminoglycoside antibiotics to mammalian cells results in the release of GPI-anchored proteins: M. Kung, et al.; FEBS Lett. 409, 333 (1997)
  • The effects of G418 on the growth and metabolism of recombinant mammalian cell lines: C.A. Yallop & I. Svendsen; Cytotechnology 35, 101 (2001)
  • Cytochrome c release and endoplasmic reticulum stress are involved in caspase-dependent apoptosis induced by G418: Q.H. Jin, et al.; Cell. Mol. Life Sci. 61, 1816 (2004)
  • Expression and distribution of HSP27 in response to G418 in different human breast cancer cell lines: L. Qian, et al.; Histochem. Cell Biol. 126, 593 (2006)
  • Antiviral activity of geneticin against bovine viral diarrhoea virus: A.V. Birk, et al.; Antivir. Chem. Chemother. 19, 33 (2008)
  • Antiviral activity of geneticin against dengue virus: X.G. Zhang, et al.; Antiviral Res. 83, 21 (2009)