GABAA receptor agent 2 (TFA) [1781880-44-1]

MedChem Express

GABAA receptor agent 2 (TFA) [1781880-44-1]

10

1781880-44-1

Research Use Only

C22H22F3N3O3

433.42

GABAA receptor agent 2 TFA is a potent and high-affinity GABAA receptor antagonist with an IC50 of 24 nM (human alpha1beta2gamma2 GABAA-expressing tsA201 cells) and a Ki of 28 nM (rat GABAA receptors). GABAA receptor agent 2 TFA is inactive against four human GABA transporters (hGAT-1, hBGT-1, hGAT-2, and hGAT-3)[1].

ON1N=CC(C2CCNCC2)=C1C3=CC(C4=CC=CC=C4)=CC=C3.OC(C(F)(F)F)=O

12131703