GAD1 Polyclonal Antibody
RD70110A
ApplicationsImmunoHistoChemistry
Product group Antibodies
ReactivityMouse
TargetGad1
Overview
- SupplierReddot Biotech
- Product NameGAD1 Polyclonal Antibody
- Delivery Days Customer5
- ApplicationsImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration2 mg/ml
- ConjugateUnconjugated
- Gene ID14415
- Target nameGad1
- Target descriptionglutamate decarboxylase 1
- Target synonyms67 kDa glutamic acid decarboxylase; EP1; EP10; Gad-; Gad-1; GAD2; GAD4; GAD6; glutamate decarboxylase 1; glutamic acid decarboxylase 1
- HostRabbit
- IsotypeIgG
- Scientific DescriptionThis gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.
- ReactivityMouse
- Storage Instruction-20°C
- UNSPSC12352203