gamma-Secretase modulator 12 [2204249-82-9]

MedChem Express

gamma-Secretase modulator 12 [2204249-82-9]

10

2204249-82-9

Research Use Only

C25H23N3O2

397.47

gamma-Secretase modulator 12 (Compound 1a) is a gamma-secretase modulator that can selectively decrease amyloid-beta42 (Abeta42) levels (IC50 of 0.39 microM). gamma-Secretase modulator 12 can be used for Alzheimers disease research. gamma-Secretase modulator 12 has a good brain/plasma ratio (Kp, brain = 0.72) in mice[1].

O=C1C2=C(CN1CC)C=C(C3=C(C)N=C4C(OCC5=CC=CC=C5)=CC=CN43)C=C2

12352200