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Chemical Structure
Chemical Structure
Chemical Structure

Ganglioside GD1a . disodium salt (bovine brain) [12707-58-3]

Research Use Only
AG-CN2-9003
AdipoGen Life Sciences
CAS Number12707-58-3
Product group Chemicals
Estimated Purity>98%
Molecular Weight1836.1 . 46.0 (calculated on sphingosine C18:1 and stearic acid)
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Packing Size
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Ganglioside GD1a . disodium salt [12707-58-3]
  • Delivery Days Customer
    10
  • CAS Number
    12707-58-3
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Molecular Formula
    C84H146N4O39 . 2Na
  • Molecular Weight
    1836.1 . 46.0 (calculated on sphingosine C18:1 and stearic acid)
  • Scientific Description
    Chemical. CAS: 12707-58-3. Formula: C84H146N4O39 . 2Na. MW: 1836.1 . 46.0 (calculated on sphingosine C18:1 and stearic acid). Isolated from bovine brain. Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GD1a is the major ganglioside of the nervous system. It is converted to GM1 by bacterial, viral and mammalian sialidases. It is a differentiation marker for cell growth. - Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GD1a is the major ganglioside of the nervous system. It is converted to GM1 by bacterial, viral and mammalian sialidases. It is a differentiation marker for cell growth.
  • SMILES
    [Na+].[Na+].[H][C@@](O)(CO)[C@]([H])(O)C1O[C@@](CC(O)[C@H]1NC(C)=O)(O[C@@H]1C(O)C(O)[C@H](OC2[C@@H](O)[C@H](CO)O[C@H](O[C@H]3C(CO)O[C@@H](O[C@H]4C(O)C(O)[C@H](OC[C@]([H])(NC(=O)CCCCCCCCCCCCCCCCC)[C@]([H])(O)\C=C\CCCCCCCCCCCCC)O[C@H]4CO)C(O)[C@H]3O[C@@]3(CC(O)[C@@H](NC(C)=O)C(O3)[C@@]([H])(O)[C@]([H])(O)CO)C([O-])=O)C2NC(C)=O)O[C@H]1CO)C([O-])=O
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Role of membrane gangliosides in the binding and action of bacterial toxins: P.H. Fishman; J. Membr. Biol. 69, 85 (1982)
  • Dynamic and structural properties of sphingolipids as driving force to the formation of membrane domains: S. Sonnino, et al.; Chem. Rev. 106, 2111 (2006)