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ProductsBack/Ganglioside GD1b . disodium salt (bovine brain) [19553-76-5]
Chemical Structure
Chemical Structure
Chemical Structure

Ganglioside GD1b . disodium salt (bovine brain) [19553-76-5]

Research Use Only
AG-CN2-9004
AdipoGen Life Sciences
CAS Number19553-76-5
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight1836.1 . 46.0 (calculated on sphingosine C18:1 and stearic acid)
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Ganglioside GD1b . disodium salt [19553-76-5]
  • Delivery Days Customer
    10
  • CAS Number
    19553-76-5
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Molecular Formula
    C84H146N4O39 . 2Na
  • Molecular Weight
    1836.1 . 46.0 (calculated on sphingosine C18:1 and stearic acid)
  • Scientific Description
    Chemical. CAS: 19553-76-5. Formula: C84H146N4O39 . 2Na. MW: 1836.1 . 46.0 (calculated on sphingosine C18:1 and stearic acid). Isolated from bovine brain. Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GD1b may act as a bacterial toxin receptor (tetanus, botulinus). High levels are found in gliomas and astrocytomas. It modulates protein kinase activities. In vivo and in vitro it is in equilibrium with the lactone structure. - Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GD1b may act as a bacterial toxin receptor (tetanus, botulinus). High levels are found in gliomas and astrocytomas. It modulates protein kinase activities. In vivo and in vitro it is in equilibrium with the lactone structure.
  • SMILES
    [Na+].[Na+].[H][C@@](O)(CO)[C@]([H])(O)C1O[C@@](CC(O)[C@H]1NC(C)=O)(O[C@@]([H])(CO)[C@]([H])(O)C1O[C@@](CC(O)[C@H]1NC(C)=O)(O[C@@H]1C(O)[C@H](O[C@H]2C(O)C(O)[C@H](OC[C@]([H])(NC(=O)CCCCCCCCCCCCCCCCC)[C@]([H])(O)\C=C\CCCCCCCCCCCCC)O[C@H]2CO)OC(CO)[C@@H]1O[C@H]1O[C@@H](CO)[C@H](O)C(O[C@@H]2OC(CO)[C@@H](O)[C@H](O)C2O)C1NC(C)=O)C([O-])=O)C([O-])=O
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Role of membrane gangliosides in the binding and action of bacterial toxins: P.H. Fishman; J. Membr. Biol. 69, 85 (1982)
  • Natural occurrence of ganglioside lactones. Isolation and characterization of GD1b inner ester from adult human brain: L. Riboni, et al.; J. Biol. Chem. 261, 8514 (1986)
  • Exogenous gangliosides GD1b and GD1b-lactone, stably associated to rat brain P2 subcellular fraction, modulate differently the process of protein phosphorylation: R. Bassi, et al.; J. Neurochem. 57, 1207 (1991)
  • Immunohistochemical staining for ganglioside GD1b as a diagnostic and prognostic marker for primary human brain tumors: T.C. Comas, et al.; Neuro Oncol. 1, 261 (1999)
  • Dynamic and structural properties of sphingolipids as driving force to the formation of membrane domains: S. Sonnino, et al.; Chem. Rev. 106, 2111 (2006)