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ProductsBack/Ganglioside GQ1b . tetrasodium salt (bovine brain) [68652-37-9]
Chemical Structure
Chemical Structure
Chemical Structure

Ganglioside GQ1b . tetrasodium salt (bovine brain) [68652-37-9]

Research Use Only
AG-CN2-9007
AdipoGen Life Sciences
CAS Number68652-37-9
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Product group Chemicals
Estimated Purity>98%
Molecular Weight2416.6 . 92.0 (calculated on sphingosine C18:1 and stearic acid)
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Ganglioside GQ1b . tetrasodium salt [68652-37-9]
  • Delivery Days Customer
    10
  • CAS Number
    68652-37-9
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Molecular Formula
    C106H178N6O55 . 4Na
  • Molecular Weight
    2416.6 . 92.0 (calculated on sphingosine C18:1 and stearic acid)
  • Scientific Description
    Chemical. CAS: 68652-37-9. Formula: C106H178N6O55 . 4Na. MW: 2416.6 . 92.0 (calculated on sphingosine C18:1 and stearic acid). Isolated from bovine brain. Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GQ1b specifically promotes neural differentiation of human neuroblastoma cells. Anti-GQ1b antibodies are present in serum from Miller-Fisher syndrome patients. - Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GQ1b specifically promotes neural differentiation of human neuroblastoma cells. Anti-GQ1b antibodies are present in serum from Miller-Fisher syndrome patients.
  • SMILES
    [Na+].[Na+].[Na+].[Na+].[H][C@@](O)(CO)[C@]([H])(O)C1O[C@@](CC(O)[C@H]1NC(C)=O)(O[C@@]([H])(CO)[C@]([H])(O)C1O[C@@](CC(O)[C@H]1NC(C)=O)(O[C@H]1[C@H](O)C(CO)O[C@@H](OC2[C@@H](O)[C@H](CO)O[C@H](O[C@H]3C(CO)O[C@@H](O[C@H]4C(O)C(O)[C@H](OC[C@]([H])(NC(=O)CCCCCCCCCCCCCCCCC)[C@]([H])(O)\C=C\CCCCCCCCCCCCC)O[C@H]4CO)C(O)[C@H]3O[C@@]3(CC(O)[C@@H](NC(C)=O)C(O3)[C@@]([H])(O)[C@]([H])(CO)O[C@@]3(CC(O)[C@@H](NC(C)=O)C(O3)[C@@]([H])(O)[C@]([H])(O)CO)C([O-])=O)C([O-])=O)C2NC(C)=O)C1O)C([O-])=O)C([O-])=O
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Role of membrane gangliosides in the binding and action of bacterial toxins: P.H. Fishman; J. Membr. Biol. 69, 85 (1982)
  • A novel glycosignaling system: GQ1b-dependent neuritogenesis of human neuroblastoma cell line, GOTO, is closely associated with GQ1b-dependent ecto-type protein phosphorylation. S. Tsuji, et al.; Neurochem. 21, 549 (1992)
  • Dynamic and structural properties of sphingolipids as driving force to the formation of membrane domains: S. Sonnino, et al.; Chem. Rev. 106, 2111 (2006)
  • Fisher syndrome: clinical features, immunopathogenesis and management. M. Mori, et al.; Expert Rev. Neurother. 12, 39 (2012)