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ProductsBack/GANT61 [500579-04-4]
Chemical Structure
Chemical Structure
Chemical Structure

GANT61 [500579-04-4]

Research Use Only
AG-CR1-3561
AdipoGen Life Sciences
CAS Number500579-04-4
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight429.6
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    GANT61 [500579-04-4]
  • Delivery Days Customer
    10
  • CAS Number
    500579-04-4
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Molecular Formula
    C27H35N5
  • Molecular Weight
    429.6
  • Scientific Description
    Cell permeable GLI antagonist. Inhibits Gli1 and Gli2-induced transcription [1]. Sonic hedgehog (Shh) signaling pathway inhibitor, downstream of SMO and SUFU [1]. Displays antiproliferative and antitumor activity in vitro and in vivo [1, 2 , 3, 4, 5]. Apoptosis inducer [1, 2 , 3, 4, 5]. - Chemical. CAS: 500579-04-4. Formula: C27H35N5. MW: 429.6. Cell permeable GLI antagonist. Inhibits Gli1 and Gli2-induced transcription. Sonic hedgehog (Shh) signaling pathway inhibitor, downstream of SMO and SUFU. Displays antiproliferative and antitumor activity in vitro and in vivo. Apoptosis inducer.
  • SMILES
    CN(C)C1=CC=CC=C1CN1CCCN(CC2=C(C=CC=C2)N(C)C)C1C1=CC=NC=C1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists: M. Lauth, et al.; PNAS 104, 8455 (2007)
  • Inhibition of GLI, but not Smoothened, induces apoptosis in chronic lymphocytic leukemia cells: P. Desch, et al.; Oncogene 29, 4885 (2010)
  • Hedgehog signaling drives cellular survival in human colon carcinoma cells: T. Mazumdar, et al.; Cancer Res. 71, 1092 (2011)
  • HH/GLI signalling as a new therapeutic target for patients with oral squamous cell carcinoma. M. Yan, et al.; Oral Oncol. 47, 504 (2011)
  • Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells: T. Mazumdar, et al.; Cancer Res. 71, 5904 (2011)