GCK Polyclonal Antibody
RD70154A
ApplicationsImmunoFluorescence, Western Blot, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse
TargetGck
Overview
- SupplierReddot Biotech
- Product NameGCK Polyclonal Antibody
- Delivery Days Customer5
- ApplicationsImmunoFluorescence, Western Blot, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID103988
- Target nameGck
- Target descriptionglucokinase
- Target synonymsGk; GLK; Gls0; Gls006; hexokinase type IV; hexokinase-4; hexokinase-D; HK IV; HK4; HKIV; Hlb6; Hlb62; HXKP; MODY; MODY2
- HostRabbit
- IsotypeIgG
- Scientific DescriptionHexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
- ReactivityHuman, Mouse
- Storage Instruction-20°C
- UNSPSC12352203