GCK Polyclonal Antibody

Reddot Biotech

GCK Polyclonal Antibody

5

ImmunoFluorescence, Western Blot, ImmunoHistoChemistry

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

Gck

glucokinase

Gk; GLK; Gls0; Gls006; hexokinase type IV; hexokinase-4; hexokinase-D; HK IV; HK4; HKIV; Hlb6; Hlb62; HXKP; MODY; MODY2

Rabbit

IgG

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).

Human, Mouse

-20°C

12352203