GCLM Antibody / Glutamate-Cysteine Ligase Regulatory Subunit

Biorbyt

GCLM Antibody / Glutamate-Cysteine Ligase Regulatory Subunit

10

ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT IHC-P

Research Use Only

Monoclonal

GCLM/4069

Unconjugated

GCLM

glutamate-cysteine ligase modifier subunit

gamma-ECS regulatory subunit; gamma-glutamylcysteine synthetase regulatory subunit; GCS light chain; GLCLR; glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory (30.8kD); glutamate-cysteine ligase modifier subunit delta2 alternative splicing; glutamate-cysteine ligase regulatory protein; glutamate--cysteine ligase regulatory subunit; GSC light chain

Mouse

IgG2a

Glutamate--cysteine ligase regulatory subunit

g-glutamylcysteine synthetase (g-GCS) is the rate limiting enzyme for glutathione (L-g-glutamyl-L-cysteinylglycine, GSH) synthesis. GSH is ubiquitous in mammalian cells as a vital intra- and extracellular protective antioxidant. g-GCS is a heterodimer of a heavy catalytic subunit and a light regulatory subunit that is responsive to inflammation, phenolic antioxidants, heat shock, oxidants and cytokines. The human g-GCS gene encoding the 367 amino acid catalytic subunit maps to chromosome 6p12. The human g-GCS gene encoding the regulatory subunit maps to chromosome 1p22.1. The two subunits of g-GCS form a heterodimeric zinc metalloprotein that gains activity through formation of a reversible disulfide bond.

Human

-20°C

12352203