GDC-0214(GDC0214)

Biorbyt

GDC-0214(GDC0214)

10

Research Use Only

C28H28ClF2N9O3

612.039

GDC0214 is a potent, selective inhalable and lung-restricted inhibitor of JAK1 with IC50 of 8.52 nM, displays 6.3/704/28 fold selectivity over JAK2/JAK3/TYK2.

C12=C(C(NC3=CN(CC(N4CCC(N(CCC#N)C)CC4)=O)N=C3C3=CC(Cl)=CC=C3OC(F)F)=O)C=NN1C=CC=N2

12352200