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ProductsBack/GE2270 D2 [138948-60-4]
Chemical Structure
Chemical Structure
Chemical Structure

GE2270 D2 [138948-60-4]

Research Use Only
AG-CN2-0304
AdipoGen Life Sciences
CAS Number138948-60-4
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Product group Chemicals
Estimated Purity>80%
Molecular Weight1276.5
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    GE2270 D2 [138948-60-4]
  • Delivery Days Customer
    10
  • CAS Number
    138948-60-4
  • Certification
    Research Use Only
  • Estimated Purity
    >80%
  • Molecular Formula
    C55H53N15O10S6
  • Molecular Weight
    1276.5
  • Scientific Description
    Chemical. CAS: 138948-60-4. Formula: C55H53N15O10S6. MW: 1276.5. Isolated from Planobispora rosea. Thiopeptide antibiotic. Congener of GE2270A. Used as a starting scaffold bearing a free hydroxy group, for the production of new interesting semi-synthetic antibiotics. Antibacterial agent by inhibiting bacterial protein synthesis. Active against numerous Gram-positive pathogens. Inhibitor of elongation factor Tu (EF-Tu). Inhibits protein synthesis by blocking the GDP to GTP conformational change and by directly competing with aminoacyl-tRNA for the same binding site on EF-Tu. - Thiopeptide antibiotic. Congener of GE2270A (AG-CN2-0303 https://adipogen.com/ag-cn2-0303-ge2270a.html ). Used as a starting scaffold bearing a free hydroxy group, for the production of new interesting semi-synthetic antibiotics. Antibacterial agent by inhibiting bacterial protein synthesis. Active against numerous Gram-positive pathogens. Inhibitor of elongation factor Tu (EF-Tu). Inhibits protein synthesis by blocking the GDP to GTP conformational change and by directly competing with aminoacyl-tRNA for the same binding site on EF-Tu.
  • SMILES
    OCC1=C(C(NCC(NC(C(C2=CC=CC=C2)O)C3=NC(C4=NC(C5=C(C=CC(C6=NC(C7=NC(C(N8C(CCC8)C(N)=O)=O)CO7)=CS6)=N5)C9=NC(C(NC(CC(NC)=O)C%10=NC(C(NC%11C(C)C)=O)=C(C)S%10)=O)=CS9)=CS4)=CS3)=O)=O)N=C%11S1
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Antibiotic GE2270 a: a novel inhibitor of bacterial protein synthesis. I. Isolation and characterization: E. Selva, et al.; J. Antibiot. 44, 693 (1991)
  • Components of the GE2270 complex produced by Planobispora rosea ATCC 53773: E. Selva, et al.; J. Antibiot. 48, 1039 (1995)
  • Contribution of mass spectrometry to the structural confirmation of components of the antibiotic GE2270 complex: L. Colombo, et al.; Rap. Commun. Mass. Spec. 9, 717 (1995)
  • Antimicrobial activities of chemically modified thiazolyl peptide antibiotic MDL 62,879 (GE2270A): S. Lociuro, et al.; J. Antibiot. 50, 344 (1997)
  • Capturing linear intermediates and C-terminal variants during maturation of the thiopeptide GE2270: A. Tocchetti, et al.; Chem. Biol. 20, 1067 (2013)
  • Elfamycins: inhibitors of elongation factor-Tu: S.M. Prezioso, et al.; Mol. Microbiol. 106, 22 (2017) (Review)