GE2270 D2 [138948-60-4]

AdipoGen Life Sciences

GE2270 D2

10

138948-60-4

Research Use Only

>80%

C55H53N15O10S6

1276.5

Chemical. CAS: 138948-60-4. Formula: C55H53N15O10S6. MW: 1276.5. Isolated from Planobispora rosea. Thiopeptide antibiotic. Congener of GE2270A. Used as a starting scaffold bearing a free hydroxy group, for the production of new interesting semi-synthetic antibiotics. Antibacterial agent by inhibiting bacterial protein synthesis. Active against numerous Gram-positive pathogens. Inhibitor of elongation factor Tu (EF-Tu). Inhibits protein synthesis by blocking the GDP to GTP conformational change and by directly competing with aminoacyl-tRNA for the same binding site on EF-Tu. - Thiopeptide antibiotic. Congener of GE2270A (AG-CN2-0303 https://adipogen.com/ag-cn2-0303-ge2270a.html ). Used as a starting scaffold bearing a free hydroxy group, for the production of new interesting semi-synthetic antibiotics. Antibacterial agent by inhibiting bacterial protein synthesis. Active against numerous Gram-positive pathogens. Inhibitor of elongation factor Tu (EF-Tu). Inhibits protein synthesis by blocking the GDP to GTP conformational change and by directly competing with aminoacyl-tRNA for the same binding site on EF-Tu.

OCC1=C(C(NCC(NC(C(C2=CC=CC=C2)O)C3=NC(C4=NC(C5=C(C=CC(C6=NC(C7=NC(C(N8C(CCC8)C(N)=O)=O)CO7)=CS6)=N5)C9=NC(C(NC(CC(NC)=O)C%10=NC(C(NC%11C(C)C)=O)=C(C)S%10)=O)=CS9)=CS4)=CS3)=O)=O)N=C%11S1

-20°C,2°C to 8°C

12352200