GeA-69 [2143475-98-1]

AdipoGen Life Sciences

GeA-69 [2143475-98-1]

10

2143475-98-1

Research Use Only

>95%

C20H16N2O

300.4

Chemical. CAS: 2143475-98-1. Formula: C20H16N2O. MW: 300.4. Potent, selective, allosteric inhibitor of macrodomain 2 of poly-adenosine-diphosphate-ribose polymerase 14 (PARP-14 M2) (Kd=0.86microM, ITC (isothermal titration calorimetry) assay). PARP-14 is an anti-apoptotic pro-survival protein associated with inflammatory diseases and several types of cancer. Engages PARP-14 MD2 in intact cells displaces adenosine diphosphate ribose (ADPR) from PARP-14 M2 and prevents recruitment of the PARP-14 M2 to DNA damage sites. - Potent, selective, allosteric inhibitor of macrodomain 2 of poly-adenosine-diphosphate-ribose polymerase 14 (PARP-14 M2) (Kd=0.86microM, ITC (isothermal titration calorimetry) assay). PARP-14 is an anti-apoptotic pro-survival protein associated with inflammatory diseases and several types of cancer. Engages PARP-14 MD2 in intact cells displaces adenosine diphosphate ribose (ADPR) from PARP-14 M2 and prevents recruitment of the PARP-14 M2 to DNA damage sites.

O=C(C)NC1=CC=CC=C1C2=CC=CC3=C2NC4=CC=CC=C43

-20°C,2°C to 8°C

12352200