Gefitinib dihydrochloride [184475-56-7]
HY-50895B
CAS Number184475-56-7
Product group Chemicals
Molecular Weight519.82
Overview
- SupplierMedChem Express
- Product NameGefitinib dihydrochloride [184475-56-7]
- Delivery Days Customer10
- CAS Number184475-56-7
- CertificationResearch Use Only
- Molecular FormulaC22H26Cl3FN4O3
- Molecular Weight519.82
- Scientific DescriptionGefitinib (ZD 1839) dihydrochloride is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib dihydrochloride selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib dihydrochloride also induces autophagy and cell apoptosis, which can be used for cancer related research, such as Lung cancer and breast cancer .
- SMILESCOC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCN4CCOCC4.[H]Cl.[H]Cl
- Storage InstructionSee Manual
- UNSPSC12352200