Gelsolin / Actin-depolymerizing Factor(CPTC-Gelsolin-1), CF405S conjugate, 0.1mg/mL [26628-22-8]

Biotium

Gelsolin / Actin-depolymerizing Factor(CPTC-Gelsolin-1), CF405S conjugate, 0.1mg/mL

9

Research Use Only

Monoclonal

CPTC-Gelsolin-1

0.1 mg/ml

Other Conjugate

GSN

gelsolin

actin-depolymerizing factor; ADF; AGEL; brevin; epididymis secretory sperm binding protein; gelsolin

Mouse

IgG1

Gelsolin

Gelsolin (also known as brevin, Actin-depolymerizing factor or ADF), a protein of leukocytes, platelets and other cells, severs Actin filaments in thepresence of submicromolar calcium, thereby isolating cytoplasmic Actin gels. It is a calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. Defects in GSN are the cause of amyloidosis type 5 (AMYL5); also known as familial amyloidosis Finnish type, typically characterized by cranial neuropathy and lattice corneal dystrophy. Severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

Bovine, Human, Mouse

2°C to 8°C

12352203