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Geminin / DNA Replication Inhibitor(CPTC-GMMN-1), CF405S conjugate, 0.1mg/mL [26628-22-8]

Geminin / DNA Replication Inhibitor(CPTC-GMMN-1), CF405S conjugate, 0.1mg/mL [26628-22-8]

BNC042240
Biotium
ApplicationsImmunoFluorescence
Product group Antibodies
ReactivityBovine, Human, Mouse
TargetGMNN
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Overview

  • Supplier
    Biotium
  • Product Name
    Geminin / DNA Replication Inhibitor(CPTC-GMMN-1), CF405S conjugate, 0.1mg/mL
  • Delivery Days Customer
    9
  • Applications
    ImmunoFluorescence
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    CPTC-GMMN-1
  • Concentration
    0.1 mg/ml
  • Conjugate
    Other Conjugate
  • Gene ID51053
  • Target name
    GMNN
  • Target description
    geminin DNA replication inhibitor
  • Target synonyms
    Gem; geminin; MGORS6
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDO75496
  • Protein Name
    Geminin
  • Scientific Description
    Geminin is a nuclear protein that regulates the initiation of DNA replication during the cell cycle. DNA replication requires the coordinated association of Cdc6 and minichromosome maintenance (MCM) proteins with chromatin. Geminin blocks this assembly of the MCM into the prereplication complex and, in turn, prevents replication from occurring. Expression of Geminin fluctuates throughout the cell cycle with Geminin levels lowest at G1. Throughout S, G2 and M phases, Geminin levels are consistently elevated followed by a decrease during mitosis. The initiation of DNA replication is dependent on the degradation of Geminin during mitosis and the absence of Geminin throughout G1 phase. Geminin degradation is mediated by the anaphasepromoting complex (APC), which specifically targets B-type cyclins and other proteins containing a destruction box motif for degradation by ubiquitinmediated proteolysis. While geminin expression is essential in maintaining chromosomal integrity, it is frequently overexpressed in cancers and evidence suggests that it plays a significant role in tumor proliferation and progression. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
  • Source
    Animal
  • Reactivity
    Bovine, Human, Mouse
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203