GEN1 antibody

GeneTex

GEN1 antibody

9

WB: 1:500 - 1:2000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot

Research Use Only

Polyclonal

Unconjugated

GEN1

GEN1 Holliday junction 5' flap endonuclease

flap endonuclease GEN homolog 1; Gen; Gen endonuclease homolog 1; Holliday junction resolvase

Rabbit

IgG

Flap endonuclease GEN homolog 1

This gene encodes a member of the Rad2/xeroderma pigmentosum group G nuclease family, whose members are characterized by N-terminal and internal xeroderma pigmentosum group G nuclease domains followed by helix-hairpin-helix domains and disordered C-terminal domains. The protein encoded by this gene is involved in resolution of Holliday junctions, which are intermediate four-way structures that covalently link DNA during homologous recombination and double-strand break repair. The protein resolves Holliday junctions by creating dual incisions across the junction to produce nicked duplex products that can be ligated. In addition, this protein has been found to localize to centrosomes where it has been implicated in regulation of centrosome integrity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]

Human, Mouse

-20°C or -80°C,2°C to 8°C

12352203