GFI1 Polyclonal Antibody

Reddot Biotech

GFI1 Polyclonal Antibody

5

1.86 mg/ml

GFI1

growth factor independent 1 transcriptional repressor

GFI-1; GFI1A; growth factor independence-1; growth factor independent 1 transcription repressor; growth factor independent protein 1; SCN2; zinc finger protein 163; zinc finger protein Gfi-1; ZNF163

This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene.

-20°C

12352203