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GFRAL (mouse):Fc (mouse) (rec.)

Research Use Only
CHI-MF-110GFRAL
Chimerigen Laboratories
Product group Proteins / Signaling Molecules
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Overview

  • Supplier
    Chimerigen Laboratories
  • Product Name
    GFRAL (mouse):Fc (mouse) (rec.)
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Scientific Description
    GFRAL (GDNF receptor alpha-like) is a distant member of the GDNFR family of proteins. Mouse GFR alpha-like contains a 330aa extracellular domain. It is expressed on hindbrain neurons of the CNS and functions as an anti-apoptotic molecule during neuronal stress. GFRAL is a functional receptor for GDF15, facilitating weight-loss functions of the protein through c-Ret downstream signaling. GFRAL and GDF15 signaling is implicated in diet-based obesity and insulin resistance. - Recombinant protein. The extracellular domain of mouse GFRAL (aa 20-349) is fused to the N-terminus of the Fc region of mouse IgG2a. Measured by its binding ability in a functional ELISA. Source/Host: HEK 293 cells. Purity: >98% (SDS-PAGE). Lyophilized from 0.2microm-filtered solution in PBS. GFRAL (GDNF receptor alpha-like) is a distant member of the GDNFR family of proteins. Mouse GFR alpha-like contains a 330aa extracellular domain. It is expressed on hindbrain neurons of the CNS and functions as an anti-apoptotic molecule during neuronal stress. GFRAL is a functional receptor for GDF15, facilitating weight-loss functions of the protein through c-Ret downstream signaling. GFRAL and GDF15 signaling is implicated in diet-based obesity and insulin resistance.
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352202