GGTI-2166

TargetMol Chemicals

GGTI-2166

65

478908-51-9

Chemical

GGTI-2166

C25H30N4O3

434.53

GGTI-2166 is a geranylgeranyl transferase I inhibitor. GGTI-2166 inhibit the pOC formation induced by RANKL or TNF-alpha in cultures of both mouse marrow-derived macrophage-colony-stimulating factor (M-CSF) dependent monocytes (MD cells) and the mouse monocyte cell line RAW 264.7 (RAW cells). GGTI-2166 inhibited TRAP activity induced by RANKL or TNF-alpha in both cell cultures and prevented the incorporation of [3H]all-trans geranylgeraniol into prenylated proteins in RAW cells.

3 years

C(N[C@H](C(OC)=O)CC(C)C)(=O)C1=C(C=C(NCC2=CN=CN2)C=C1)C3=C(C)C=CC=C3

-20°

12352200