GGTI-2418

MedChem Express

GGTI-2418 [501010-06-6]

10

501010-06-6

Research Use Only

98.29

C23H31N5O4

441.52

GGTI-2418 is a highly potent, competitive, and selective geranylgeranyltransferase I ( GGTase I ) inhibitor. GGTI-2418 inhibits GGTase I and FTase activities with IC 50 s of 9.5 nM and 53 microM, respectively. GGTI-2418 also increases p27(Kip1) and induces significant regression of breast tumors [1] .

CC(C)C[C@@H](C(O)=O)NC(N1[C@@H](CC2=CC=CC=C2)C(N(CC3=C(C)N=CN3)CC1)=O)=O

-20°C,2°C to 8°C

12352200