More than 130 suppliers
ISO certified
In-house tech support
we Connect you
Bio-Connect
ProductsBack/GGTI-286 TFA

GGTI-286 TFA

T73822
TargetMol Chemicals
Molecular Weight543.6
DownloadMSDS
Product group Chemicals
Sign in to order and to see your custom pricing.
Large volume orders?
Order with a bulk request
More than 130 suppliers
ISO certified
In-house tech support

Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    GGTI-286 TFA
  • Delivery Days Customer
    999
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    GGTI-286 TFA
  • Molecular Formula
    C25H32F3N3O5S
  • Molecular Weight
    543.6
  • Scientific Description
    GGTI-286 TFA is a potent, cell-permeable inhibitor of GGTase I, exhibiting 25 times greater effectiveness (IC 50 = 2 microM) compared to the corresponding methyl ester of FTI-276. It specifically targets the geranylgeranylation of Rap1A, demonstrating significant selectivity over the farnesylation of H-Ras in NIH3T3 cells (IC 50s = 2 and >30 microM, respectively). Additionally, GGTI-286 TFA effectively inhibits the stimulation of oncogenic K-Ras4B with an IC 50 of 1 microM.
  • Shelf life instruction
    3 years
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200