Ginsenoside Rb3 [68406-26-8]

Selleck Chemicals

Ginsenoside Rb3 [68406-26-8]

9

68406-26-8

Research Use Only

Ginsenoside Rb3, extracted from the plant Panax ginseng, plays important roles in cardiovascular diseases, including myocardial ischemia-reperfusion (I/R) injury. Ginsenoside Rb3 (0.1-10 muM) is tested for inhibition of tumor necrosis factor-alfa (TNF)-induced nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) luciferase reporter activity using a human kidney 293T cell-based assay. Ginsenoside Rb3 shows the significant activity with an IC50 of 8.2 muM. Ginsenoside Rb3 also inhibits the induction of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) messenger Ribonucleic acid (mRNA) in a dose-dependent manner after HepG2 cells have been treated with TNF-alfa (10 ng/mL).

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