Gitoxin [4562-36-1]

Name: Gitoxin [4562-36-1]
SKU: AG-CN2-0485_A27
Price: 403 EUR
Availability: BackOrder

AG-CN2-0485

CAS Number4562-36-1

Product group Chemicals

Estimated Purity>95%

Molecular Weight780.9

Overview

Supplier
AdipoGen Life Sciences
Product Name
Gitoxin [4562-36-1]
Delivery Days Customer
10
ADR Class
6.1
CAS Number
4562-36-1
Certification
Research Use Only
Estimated Purity
>95%
Hazard Information
Danger,Excepted quantity
Molecular Formula
C41H64O14
Molecular Weight
780.9
Scientific Description
Cardiac glycoside. Natural metabolite of digitoxin. Starting material for the synthesis of gitoxin derivatives with activity as cardiac glycosides. Uncompetitive inhibitor of the Na+/K+ ATPase activity. Inhibits growth of selected human cancer cells. - Chemical. CAS: 4562-36-1. Formula: C41H64O14. MW: 780.9. Isolated from Digitalis purpurea L. Cardiac glycoside. Natural metabolite of digitoxin. Starting material for the synthesis of gitoxin derivatives with activity as cardiac glycosides. Uncompetitive inhibitor of the Na+/K+ ATPase activity. Inhibits growth of selected human cancer cells.
SMILES
O[C@@H]1[C@H](O)[C@@H](C)O[C@@H](O[C@H]([C@@H](C)O[C@@H](O[C@H]([C@@H](C)O[C@@H](O[C@H](C[C@@]2([H])CC[C@]3([H])[C@]4([H])CC[C@@]5([C@H]([C@@H](O)C[C@]35O)C(CO6)=CC6=O)C)CC[C@@]24C)C7)[C@H]7O)C8)[C@H]8O)C1
Storage Instruction
-20°C,2°C to 8°C
UN Number
UN 2811
UNSPSC
12352200

Studies on digitalis glycosides. VII. Gitoroside, digitalonin, and gitoxin pentaacetate: D. Satoh, et al.; Pharm. Bull. 5, 253 (1957)
Effects of digoxin and gitoxin on the enzymatic activity and kinetic parameters of Na+/K+-ATPase: D. Krstic, et al.; J. Enzyme Inhib. Med. Chem. 19, 409 (2004)
Na+/K+-ATPase: Activity and inhibition: M. Colovic, et al.; Russ. J. Phys. Chem. A. 83, 1602 (2009)
A structural view on the functional importance of the sugar moiety and steroid hydroxyls of cardiotonic steroids in binding to Na,K-ATPase: F. Cornelius, et al.; J. Biol. Chem. 288, 6602 (2013)
Hellebrin and its aglycone form hellebrigenin display similar in vitro growth inhibitory effects in cancer cells and binding profiles to the alpha subunits of the Na+/K+-ATPase: L. Moreno Y. Banuls, et al.; Mol. Cancer 12, 33 (2013)