GLL398

MedChem Express

GLL398 [2077980-80-2]

10

2077980-80-2

C25H23BO4

398.26

GLL398 is a potent, orally bioavailable selective estrogen receptor degrader ( SERD ) with an IC 50 value of 1.14 nM. GLL398 shows a strong dose-dependent binding to ER with a mutation at Y537S ( IC 50 =29.5 nM). GLL398 blocks tumor growth in xenograft models of breast cancer.

OC(/C=C/C(C=C1)=CC=C1/C(C2=CC=C(B(O)O)C=C2)=C(C3=CC=CC=C3)/CC)=O

12352200